effect of zingiber officinale (ginger rhizomes) hydroethanolic extract on hyoscine-induced memory impairment in adult male rats

Authors

ali gomar department of biology, science & research institute, islamic azad university, tehran, iran

abdolkarim hosseini department of physiology, faculty of biological science, shahid beheshti university, tehran, iran

naser mirazi department of biology, faculty of basic sciences, bu-ali sina university, hamedan, iran

mojtaba gomar department of surgical technology, faculty of para medicine, aja university of medical sciences, tehran, iran

abstract

background: the spice zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. in this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the hyoscine-induced memory impairment in rats. methods: in this experimental study 64 male wistar rats were divided into eight groups (8 rats in each group): normal saline, hyoscine (1 mg/kg), ginger extract (50, 100 and 200 mg/kg), or hyoscine (1 mg/kg) plus ginger extract (50, 100 and 200 mg/kg). memory impairment was induced by a single injection of hyoscine (1 mg/kg, i.p). cognitive functions were evaluated using passive avoidance learning (pal) task. retention test was carried out 24 h after training, and the latency of entering the dark compartment [step-through latency (stl)] and the total time in the dark compartment (tdc) were recorded. all statistical analysis was carried out at 5% level of significance using spss version 21. the data were analyzed by anova followed by tukey’s test. results: the time latency in hyoscine-treated group was lower than control (133.87±14.60 vs. 242.12±10.58; p<0.001, respectively). treatment of the animals by 100 and 200 mg/kg of ginger extract before the training trial increased the time latency at 24 h after the training trial (277±4.67 and 280.37±7.68; p<0.01, respectively). administration of both 100 and 200 mg/kg doses of the extract in hyoscine received animal groups before retention trials also increased the time latency than the hyoscine-treated groups (247.37±7.62 and 271.87±9.11; p<0.001, respectively). conclusion: the results revealed that the ginger hydroethanolic extract attenuated hyoscineinduced memory impairment.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

ameliorating effect of zingiber officinale (ginger) hydroethanolic extract on scopolamine-induced memory impairment in adult male rats

background and aims: the spice zingiber officinale or ginger possesses antioxidant and neuroprotective effects. in this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would have an effect on the scopolamine-induced memory impairment in rats.methods: in this experimental study, 64 male wistar rats were divided into eight groups (8 rats in ...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Aeroponic Cultivation of Ginger (Zingiber officinale) Rhizomes

Ginger (Zingiber officinale Rosc.) rhizomes are popular as a spice and an herbal dietary supplement. The anti-inflammatory and anti-nausea qualities of ginger have applications in the pharmaceutical industry. Conventionally grown as a tropical field crop, ginger is plagued by soil-borne disease and nematode problems. Aeroponic cultivation of ginger can provide high-quality rhizomes that are fre...

full text

The Prophylactic Effect of Hydroalcoholic Extract of Zingiber Officinale (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats

BACKGROUND Ginger is a natural dietary component with antioxidant and anti-carcinogenic properties. This study was conducted to evaluate the prophylactic effect of ginger extract on ethanol-induced reproductive toxicity in male rats by measuring the total homocysteine (tHcy), trace elements, antioxidant enzymes activity including glutathione peroxidase, superoxide dismutase (SOD) and catalase, ...

full text

The Protective Effect of Hydroalcoholic Extract of Zingiber officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats

This study was conducted to evaluate the prophylactic effect of ginger extract on ethanol-induced reproductive toxicity in male rats. Twenty-eight adult male Sprague-Dawley rats were randomly divided into 4 groups and treated daily for 28 days as follows: control, control-ginger (1 g/kg of body weight [BW]/day by gavage), ethanol group (ethanol 4 g/kg of BW/day by gavage), and ginger-ethanol gr...

full text

PROTECTIVE EFFECTS OF GINGER (Zingiber officinale) EXTRACT AGAINST LEAD INDUCED OXIDATIVE STRESS ON LIVER ANTIOXIDANT ENZYMES IN MALE ALBINO RATS

In the present study, ethanolic extract of ginger on lead acetate induced toxicity was studied in male wistar albino rats. Seven groups of rats were used in the study. Glutathione peroxidase, Glutathione reductase, Glutathione-S-transferase, Catalase and Superoxide dismutase were decreased in lead acetate treated (200mg/kg body weight, once daily for eight weeks) group. However treatment with e...

full text

My Resources

Save resource for easier access later


Journal title:
international clinical neurosciences journal

جلد ۲، شماره ۳، صفحات ۱۰۵-۱۱۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023